The FDA’s Guidance on Adaptive Design is Clear.

Access our fundamental researches and applications on innovative trial design, dynamic data monitoring, machine learning and AI technology for future clinical trials

Original Articles

Stochastically Curtailed Tests In Long–Term Clinical Trials

K.K. Gordon Lan Richard Simon Max Halperin

Statistical Monitoring Of Clinical Trials

K. K. Gordon Lan, Michael A. Proschan and Janet Wittes

Methods For Flexible Sample-Size Design In Clinical Trials: Likelihood, Weighted, Dual Test, And Promising Zone Approaches

Shih WJ, Li G, Wang Y (2016)

Data Monitoring For The Chinese Clinical Trials Of Remdesivir In Treating Patients With COVID‑19 During The Pandemic Crisis

Shih WJ, Yao C, Xie T (2020)

Remdesivir Is Effective For Moderately Severe Patients: A Re-Analysis Of The First Double-Blind, Placebo-Controlled, Randomized Trial On Remdesivir For Treatment Of Severe COVID-19 Patients Conducted In Wuhan City

Weichung J. Shih1, Xin Shen, Peng Zhang, Tai Xie (2020)

Dynamic Monitoring Of On-Going Clinical Trials

Tai Xie, Peng Zhang, Weichung Joe Shih, Yue Tu, K.K. Gordon Lan

(submitted manuscript, 2020)