The FDA’s Guidance on Adaptive Design is Clear.
Access the relevant research to see how machine learning and AI technology supports the FDA guidance on well-established fundamental statistical theories.
Optimizing Trial Design: Sequential, Adaptive, and Enrichment Strategies
Cyrus Mehta, Ping Gao, Deepak L. Bhatt, Robert A. Harrington, Simona Skerjanec and James H. Ware
Adaptive Designs for Noninferiority Trials
Ping Gao, Lingyun Liu, and Cyrus Mehta
Adaptive Sequential Testing for Multiple Comparisons
Ping Gao, Lingyun Liub & Cyrus Mehta
Sample Size Re-Estimation for Adaptive Sequential Design in Clinical Trials
Ping Gao, James H. Ware, and Cyrus Mehta
Population Enrichment Designs: Case Study of a Large Multinational Trial
Cyrus R. Mehta, Ping Gao